Full findings from NASA ‘Twins Study’ raise more questions about long stints in space

Full findings from NASA ‘Twins Study’ raise more questions about long stints in space

7:00am, 12th April, 2019
The genetic and health profiles of Mark Kelly and Scott Kelly were compared during a “Twins Study” focusing on the effects of long-term spaceflight. (NASA Photo) Ten research teams today shared comprehensive scientific results from an unprecedented experiment to gauge the health differences that developed between an astronaut who spent nearly a year in space and his identical twin down on Earth. The study, , traces the results of DNA tests and analyses of biological samples from Scott Kelly, who took on the 340-day mission on the International Space Station in 2015-2016; and from his brother Mark Kelly, a former astronaut who underwent parallel tests on Earth. Many of the findings have been , but today’s open-access research paper and supporting materials provided broader context for the — and pointed to concerns that are likely to be addressed in future space experiments. Previous reports have noted that Scott Kelly experienced changes in his medical condition during his long stint in space, but that most of those changes were reversed after his return. For example, the makeup of Scott’s gut microbiome shifted, perhaps due to a change in diet, and then shifted back after his flight. Patterns of gene expression also changed, particularly in genetic regions associated with the immune system and DNA repair. More than 90 percent of those changes reversed themselves, but some of the changes persisted six months after Scott’s landing. (, only the patterns of which genes were switched on or off.) The detailed findings highlight some concerns about long-lasting effects of long-term spaceflight. Scott’s exposure to radiation in space, for example, led to minor mutations in his chromosomes. “Some of the chromosome rearrangements that we saw, particularly inversions, were persistent,” Susan Bailey, a radiation biologist at Colorado State University, acknowledged during a teleconference. Another genetic change had to do with the length of Scott’s telomeres — that is, the molecular end caps on his chromosomes. They’ve been compared to the protective ends on shoelaces, and they tend to get shorter as a person ages. Geneticists were intrigued to find that Scott’s telomeres actually lengthened during his spaceflight, but became shorter when he was back on Earth. “When we looked at individual telomere length and distributions, he did have many more short telomeres after flight than he did before,” Bailey said. “So in that sense, or from the perspective of aging and health risks, that could be where he might be at increased risk for … cardiovascular disease, for example, or some types of cancer.” The shape of Scott’s eyeballs changed in weightlessness, leading to the types of vision problems that have been found among male astronauts (but not so much among female astronauts). Scott also registered a slight loss in cognitive abilities when he returned to Earth, although it’s not clear whether that’s related to long-term spaceflight. The researchers suspected that it’s more likely the result of the added stress he experienced as he readjusted to earthly routines. The now-retired astronaut has acknowledged that it took at least six months for him to readjust fully. The researchers cautioned against reading too much into their study. “We’re only studying an n of one — in other words, there’s just one twin pair here — and we’re not corroborating the results in this study by looking at other astronauts,” said Andy Feinberg, director of the Center for Epigenetics at Johns Hopkins University and one of the lead investigators on the Twins Study. Nevertheless, the findings point to issues that will have to be resolved as NASA plans for trips beyond Earth orbit, to the moon, Mars and beyond. “We’re looking forward to these results serving as a guide and foundation for future studies and things we need to be aware of and look at in astronauts in upcoming longer-duration missions [going] deeper and deeper in space,” Bailey said. In a , the University of Darmstadt’s Markus Löbrich and the University of Sussex’s Penny Jeggo said studying the health impacts of long-term spaceflight, particularly exposure to space radiation, should be a high priority. The newly published study “represents more than one small step for mankind in this endeavor,” they wrote. Francine Garrett-Bakelman of the University of Virginia School of Medicine is the lead author of the study published in Science, More than 80 other researchers are co-authors.
10 things I’ve learned in 10 years of entrepreneurship with 10-yr-old twins

10 things I’ve learned in 10 years of entrepreneurship with 10-yr-old twins

6:00am, 8th May, 2018
Peter Chee hiking with his 10-year-old twin sons on a past trip to Zion National Park, Utah. He marked 10 years of entrepreneurship on May 1. (Photo Courtesy Peter Chee) [Editor’s Note: is founder and CEO of Seattle-based .] I’ve been reflecting on my journey over the last 10 years of being an entrepreneur with my boys, Max, Sam and Josh, of which Sam and Josh are 10 years old. I’ve been having them reflect back on their 10-year life journey too. Through this journey, I’ve experienced some amazing highs and crazy lows. I’ve made some good choices and had some fantastic experiences that I lean on which remind myself that I can accomplish things I never thought I could. I also see a string of mistakes that I’ve made which still sting with pain like a cut on my foot while getting hit by a wave of salt water at the beach. It’s uncomfortable, but, in a healthy way. Put your name on your list Back in the first year of running the company, I hired Sonya Stoklosa, an executive coach who was a former Olympic Trials athlete. I resonate with someone who has an athlete mindset and applies that to business. One of the most critical questions she asked me was to make a list of the 10 most important people who I care about. After looking at that list, she said to me, why isn’t my name on it? My response was I have to take care of other people; I don’t have time for myself. Her response was if you don’t take care of yourself, how could you take care of others? It was this one question that spawned off a lot of shifts and changes in my life and business. Don’t be afraid to fail I intentionally make sure my kids see me falling down. They have even said to me, “get back up and try again.” Life of being an entrepreneur isn’t a highlight reel of success. I’ve learned that while it’s important to have a lot of grit and push really hard, it’s much more about resilience from failure. It’s about getting up quickly after falling. The most important part of failure is to keep running at it, not away from it. Eventually, if you spend enough time running towards something, it will get a lot less scary and difficult. Define and defend Keep intact the things you cherish the most. For me, my non-negotiables are: I’m showing up for my three boys Max, Sam, and Josh no matter what. When I asked them, “does Dad show up?” their response isn’t going to allow me to win Dad of the Year Awards, but “yes most of the time” is a pretty solid response. My health. Wake up at 5 a.m. no matter what bad choices I’ve made the night before and start my day with exercise. Push as hard as I possibly can and recharge with the same level of intensity. The hardest part is once you define it, you have to also defend it ferociously. Do this and it will help make decisions simpler. Measure your feelings While measuring feelings sounds subjective or maybe even impossible it can be done. Start by doing this on the first day of each month and come up with one-word summaries for these things and ask yourself how you were feeling over the last 30 days: Mentally Emotionally Relationally Physically Spiritually Then for each of these things assign a number between minus five (-5) worst it has ever been and plus five (+5) best that it has ever been and where zero is your personal normal. Once you begin to track these things you’ll see trends and from there you can make conscious choices to give energy towards the category that you want to see change. It wasn’t until I had amassed a year of data that I threw this information into a spreadsheet and saw these trends. I also started to reflect back at those past months and ask myself what did I do to make some months so much better than others? Why can’t everything be fun? In this framework, everything has to be fun. There are three categories: Type 1 Fun, which is quick. Type 2 Fun, which is moderate. Type 3 Fun, which is big impact. Here are some examples of my Type 1 Fun: checking email, talking with a new customer, having a glass of wine with a friend and having a good conversation. Type 2 Fun: talking with a mentor that is 10x where you’re at, strategic planning, coming up with a go-to-market strategy, going for a 5-mile run, learning to swim. Type 3 Fun: launching a new location, forming a new partnership with a big company, running a marathon, swimming across Lake Washington, hiking Mailbox Peak. So for me, it’s simple, I need to spend more time doing Type 2 and 3 Fun. Just remember to define your own list, some of the things on my list could be total torture to another person. Once you start to schedule in these kinds of things into your day and week, protect your schedule and see the impact on how you feel. Your personal core values My personal core values became clear to me over this last 10 years. They are: Adventure Challenge Relationships. In the darkest times of running your company when everything comes into question as to whether or not you’re doing the right thing, take a look at what you’re working on and ask yourself where you’re spending your time. If you’re spending all of your time on things you don’t enjoy, you don’t have to quit your company, you can hire someone who really enjoys doing those things and focus your time on the things that are in alignment with your personal core values. Be the best version of yourself and let that drive the business. Don’t let the circumstances of the business drive you. Your identity is not your company Yes, you’re spending so much time focused on your company and chances are after 10 years, people will associate you with the brand of your company. Through the successes and failures of your company, those things do not define you and if you get to the point where you successfully exit your company, you’re not exiting yourself. If you’re a parent, you’re not defined by your children either and some could say that you care about your company and your children similarly. Yes, you love them with all your heart, but, they do not define you. Do other things that provide you personal accomplishment. For me, I’m a marathoner and an Ironman in-training. These other activities give me confidence, reduce my stress, provide me focus, and allow me to invest in myself. Pay Yourself Yes, there are sacrifices that you have to make. Sometimes cash flow is so tight that you fear you might miss payroll. This is always the most stressful and scariest thing that can happen. If you’re bootstrapping, the first thing that happens when cash flow is really tight is you pay your employees and don’t pay yourself. If you’ve raised money and cash flow is tight or you are not hitting your goals, your board or investors may ask you to lay off employees. Either way, you’re in a situation where you’re going to have to make hard decisions. The key thing is to pay yourself. You’re putting everything at risk and setting aside 10 percent profit for that level of risk needs to be ferociously defended. Once you set that aside, you won’t have any regrets, and, the company will learn to adjust itself on the expense side. Leaders in charge of profit and cost centers will innovate in order to survive and eventually thrive. Hire a coach The number one reason is accountability. Hire someone who is going to be asking you hard questions, helping you set goals, and holding you accountable. They can provide you an unbiased perspective on what you’re dealing with. If you can’t afford to hire a coach, bring on advisors to your company. These advisors should be people who are 10x where you are at. Set a regular time to meet and ask them to hold you accountable to your goals. These people don’t judge you, they support you, and just want you to succeed. This is a game-changer. Don’t worry about what other people think After reflecting and talking with my boys, the things that they said they learned were to not worry about what others think of them and it is not going to be as bad as you think. The thing that they are most proud of is hiking up Angels Landing in Zion National Park, Utah.